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ProImmune Special Assay Service
The Special Assay Service
Bespoke immunology assays based on ProImmune’s unique platform
ProImmune offers unique assays with a broad range of applications in
research immunology, including:
• Immune modulation assessment
• Managing drug immunogenicity risk
• Characterizing responses to new antigens
• All aspects of immune monitoring
• Comparison of patients to healthy donors
Researchers often approach us to ask for
bespoke assays. Usually our standard assays can be readily adapted to suit
your requirements. Our customer service team are Ph.D-educated
immunologists, able to understand your requirements in detail, and work
with you to find the most effective solution to your needs.
We call this our 'Special Assay Service'.
Our standard assays include:
Measuring antigen presentation by dendritic
cells by identifying peptides on the cell surface
Dendritic cell culture and differentiation
T cell and Dendritic cell : T cell proliferation assays
An extensive range of MHC class I and class II peptide binding assays
T and B cell ELISpot assays
Flow cytometric assays including intracellular staining
Protein and Peptide microarrays
Cell processing and storage for cellular assays
We can use any of these experimental platforms
as a basis on which to build a custom assay for your needs. For example,
at the same time as measuring T cell proliferation, we can measure
cytokine release and T cell differentiation, bringing several of our areas
of expertise together. Assays like these could take months for you to
develop and qualify in-house, but for us, adapting a standard protocol is
something we’re used to doing, usually in a matter of days.
Our custom assays
How have we helped our clients so far?
The majority of the custom work we perform is
confidential, but in the last year we have carried out a collection of
Sourcing 20 donors with a known vaccination
status to carry out ELISpot testing for T cell responses to a collection
of proteins (7 weeks from order to delivery).
A modified version of our MHC-binding assay to
derive detailed MHC-binding information for a biologic (8 weeks from order
A T cell proliferation assay on donors of a
specific HLA type, following both CD4+ and CD8 + T cell responses in the
same assay (5 weeks from order to delivery).
Contact us to
discuss your ideas, and combine them with ours.