Peptides can be used in a wide variety of research applications:
The tracking of immune responses after a particular drug treatment or immunization is a useful way of monitoring the effectiveness of treatments. There are numerous methods used for the purposes of monitoring immune responses.
ELISPOT
Intracellular Cytokine Staining
Proliferation Assays
CFSE
3H Thymidine
The aim of epitope mapping projects is to identify and characterize novel epitopes from a protein that are recognized by the immune system. By identifying novel epitopes, strategies can be developed to produce immunotherapies or vaccines for a wide range of disease areas such as cancers or infectious diseases.
T cell Epitope Discovery
MHC Peptide Binding Assays
B Cell Epitope Mapping
ELISA
Inhibition Assays
The phosphorylation/dephosphorylation process is regulated by kinases and phosphatases respectively. Many hundreds of these individual enzymes have been identified and disruption to any one of them can have multiple effects on downstream pathways. A variety of disease pathologies, particularly cancer, have been associated with mutations or deletions in signalling pathways, making the identification of new kinases and phosphatases, and also their inhibitors, an important target for many research projects.
Kinase Assays
Radio-labeled Kinase Assay
ELISA Based Assay
Fluorescent Based Assay
Fluorescence Polarization Assay
Fluorescence Resonance Energy Transfer (FRET)
Time Resolved Fluorescence (TRF)
Mobility Shift Assays
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