Anti-Idiotype-Ankyrons

Anti-Idiotype Ankyrons™

a game-changer for developing assays to track target-specific antibodies

Take the pain out of targeting the idiotype of your antibodies

Detecting and targeting specific antibody idiotypes is key for developing effective tracking assays for drug antibodies. Developing monoclonal and eventually recombinant anti-drug idiotype antibodies for such purposes has been possible but time-consuming and expensive.

Ankyrons provide a clear and powerful solution to this problem. Selected directly in vitro from our Teralibrary we already offer a growing range anti-drug idiotype Ankyrons, including against already approved therapeutic antibodies for Herceptin® (trastuzumab), Erbitux® (cetuximab), Avastin® (bevacizumab), Humira® (adalimumab), and Rituxan® (rituximab). Using guided selection we are able to select idiotype-specific Ankyrons quickly confirming non-binding to unrelated drug antibodies and other Ig subtypes.

Contact us with your Custom Ankyron™ requirements or Request a Quote for us to make a quantum leap in your idiotype targeting project.

Data for Avastin® (bevacizumab) idiotype-specific Ankyron binding

Figure. Avastin® (bevacizumab) idiotype-specific Ankyron binding. Non-binding to other drug antibodies and Ig isotypes/sub-classes is shown at high signal-to-noise ratio.

ANK_IDTarget Name (UniprotID)Protein NameKeywordsCloneID (Signal:Noise)Applications
ANK00067DRUG_BevacizumabAnkyron anti-AVASTIN, Bevacizumab antibody replacementmedicine, anti-idiotypeAB40625 (1742)
AB40628 (1152)
AB40629 (956)
AB40624 (312)
AB40630 (164)
AB40626 (119)
ANK00068DRUG_AlemtuzumabAnkyron anti-CAMPATH, Alemtuzumab antibody replacementmedicine, anti-idiotypeAAS10262 (6517500)
AAS10274 (3865000)
AAS10263 (242875)
AAS10285 (126462)
AB40613 (107450)
AAS10286 (79120)
ANK00069DRUG_CetuximabAnkyron anti-ERBITUX, Cetuximab antibody replacementmedicine, anti-idiotypeAB40622 (68)
AB40623 (37)
AB40621 (32)
ANK00070DRUG_TrastuzumabAnkyron anti-HERCEPTIN, Trastuzumab antibody replacementmedicine, anti-idiotypeAJ30466 (11829)
AG40301 (9076)
AE50364 (6305)
AE50365 (4941)
AE50366 (4017)
AE50367 (3730)
ANK00071DRUG_AdalimumabAnkyron anti-HUMIRA, Adalimumab antibody replacementmedicine, anti-idiotypeAB40638 (38095)
AB40643 (14814)
AB40644 (13488)
AB40639 (5602)
AB40640 (4723)
AB40646 (4048)
ANK00074DRUG_DenosumabAnkyron anti-Denosumab antibody replacementmedicine, anti-idiotypeBH40224 (22223)
BN30101 (4792)
BN30102 (1324)
BH40225 (925)
BH40110 (449)
BN30103 (91)
ANK00077DRUG_InfliximabAnkyron anti-Infliximab antibody replacementmedicine, anti-idiotypeBH40196 (8554)
BH40201 (6878)
BH40202 (5089)
BH40203 (5002)
BH40105 (4289)
BH40204 (4169)
ANK00079DRUG_RituximabAnkyron anti-RITUXAN, Rituximab antibody replacementmedicine, anti-idiotypeAE40312 (125137)
AE40313 (118101)
AE40314 (108432)
AE40315 (99163)
AE40316 (84946)
AE40317 (65380)
ANK00080DRUG_PalivizumabAnkyron anti-Palivizumab antibody replacementmedicine, anti-idiotypeBH40346 (34)
ANK03316DRUG_Glatiramer acetateAnkyron anti-COPAXONE, Glatiramer acetate antibody replacementmedicine, anti-idiotypeAE50378 (19)
ANK03321DRUG_PanitumumabAnkyron anti-VECTIBIX, Panitumumab antibody replacementmedicine, anti-idiotypeAE50358 (26040)
AE40336 (11506)
AE50359 (8320)
AE40337 (5376)
AE50360 (3974)
AE50361 (1589)
ANK03552DRUG_AbataceptAnkyron anti-ORENCIA, Abatacept antibody replacementmedicine, anti-idiotypeBH40388 (20)
BH40389 (15)
ANK03553DRUG_PembrolizumabAnkyron anti-Keytruda, Pembrolizumab antibody replacementmedicine, anti-idiotypeBH40177 (21785)
BH40178 (12743)
BH40179 (10766)
BH40180 (7803)
BN30105 (3478)
BH40181 (2092)
ANK03554DRUG_SecukinumabAnkyron anti-Cosentyx, Secukinumab antibody replacementmedicine, anti-idiotypeBN30108 (1415500)
BN30109 (912300)
BN30110 (750800)
BN30111 (454100)
BN30112 (443300)
BN30113 (383200)