Customer Research Case Studies

Our customers continually publish their research into a huge range of subjects.  Here we present selected case studies and editorials, highlighting different applications of our technologies, from epitope discovery to vaccine development, and combined with techniques such as magnetic separation and intracellular staining.

Synopses of customer research into the following areas are presented below:

Allergy	Haemophilia	Influenza
Autoimmunity	Hepatitis (HBV and HCV)	NKT cells and CD1d
Cancer	HIV	Other Viral diseases
CMV	Infectious Diseases	Transplantation
EBV

 

Allergy

Katharina Steinitz, Baxter, Austria
What causes adverse reactions to Factor VIII treatment?

Julio Delgado, University of Utah
The Who How and Why of Seafood Allergy, using ProImmune’s Antigen Characterization Platform

T cell Assays for Allergenicity Testing: How do Functionally Similar Proteins Compare in their Immunogenicity?

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Autoimmunity

Dolores Jaraquemada, Universitat Autònoma de Barcelona
Grave’s Disease Peptides are Characterized using ProImmune Class II REVEAL Binding Assay

Philippe Blancou, INSERM Identification of New Epitopes in Type 1 Diabetes        Lena Israelsson, Karolinska Institute Defining Autoantibody Binding to Citrullinated Target Proteins in Rheumatoid Arthritis using Peptide Arrays

Kaare Engkilde, University of Copenhagen
Mouse CD1d Tetramers Used to Correlate NKT Cell Activity with Protection from Type 1 Diabetes

Damien Bresson, LIAI
Research Into Type I Diabetes Therapy Makes use of PEPscreen® Technology

Terrance O’Hanlon, National Institute of Environmental Health Sciences
Invited Editorial: Epitope Discovery for Inflammatory Myopathy Treatment

More Autoimmunity Publications Citing ProImmune

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Cancer

Immunovaccine Inc, Nova Scotia, Canada
Liposomes deliver an immune hit to cancer cells

Marcus Butler, Dana Farber Cancer Centre
Killer T Cells Trained for Long-lasting Anti-Cancer Effects

John Webb, British Columbia Cancer Agency
High-grade Ovarian Cancer: MHC Pentamers are Used to Investigate Immunotherapy Prospects

Ingerid Abrahamsen, Oslo University Hospital, Oslo Allogeneic T Cells May Be Targeted to B Cell Leukemia        Erlend Stronen, Radiumhospitalet Oslo Pentamers Identify Allo-restricted T Cells in Study to Advance Research Into Cancer Immunotherapy

Richard Harrop, Oxford Biomedica
Novel Epitope Detection in Phase II Trial for Colorectal Cancer

Maxim Pavlenko, Karolinska University Hospital
Epitope Discovery in Prostate Cancer: Characterizing an Immunodominant CTL Epitope of PSA in Mice

Vincenzo Cerullo, University of Helsinki
First Ever Tumor-specific Response Observed for Human Patients in Oncolytic Adenovirus Cancer Gene Therapy Study

James Wells, King’s College London
New Adjuvant Drives Unprecedented Cytotoxic T Cell Response Providing a Potent Vaccine Development Platform

Hiro Yagi, Hamamatsu University School of Medicine
Pro5® Pentamers Integral in Successful Research Into Novel Immunization Strategy

Norman Woller, Edkulla Ramakrishna, Medizinische Hochschule Hannover
Using thinkpeptides to Improve Virotherapy Against Tumor Targets

More Cancer Publications Citing ProImmune

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CMV

Claire Ventura, Sanofi Pasteur, France Finding a way to control chronic CMV infection     Daniela Weiskopf, Austrian Academy of Sciences ProImmune REVEAL® Rate assays and Pro5® Pentamers Central to Study Investigating Oxidative Stress Paul Moss, University of Birmingham Pro5® Pentamers are Used to Enrich CMV-specific T Cells for Transfusion Into Transplant Patients More CMV Publications Citing ProImmune

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EBV

Stephanie Gras, Queensland Institute of Medical Research
Analyzing Allelic Polymorphism in the T Cell Receptor and its Impact on Immune Responses in an EBV Setting

Judy Tellam, Queensland Institute of Medical Research
Pro5® MHC Class I Pentamer Combined with Intracellular Cytokine Staining Shows How Protein Translation Affects the Molecular Dynamics of Antigen Presentation

Christopher Fox, University of Birmingham Researchers Use Pro5® MHC Pentamers to Identify an Exciting New Target for EBV Treatment        Michael Uhlin, Karolinska Institute Pro5® Pentamers Central in Life-saving Procedure for PTLD Treatment Michael Uhlin, Karolinska Institute Invited Editorial: The Best Strategy for Adoptive T Cell Transfer

Suzanne Elliot, Queensland Institute of Medical Research
Pro5® MHC Class I Pentamers Used to Evaluate Vaccine Safety

John J. Miles, Cardiff University School of Medicine
Invited Editorial: Tracking the TCR Repertoire Evolution During Primary Viral Infection in Humans

More EBV publications citing ProImmune

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Haemophilia

Gouri Pandey, FDA
ProImmune REVEAL® Class II HLA-Peptide Binding Assay used to identify potential potential FVIII epitopes that increase the risk of FVIII inhibitors in African-American Haemophilia A patients compared with Caucasians

Katherine High, The Children’s Hospital of Philadelphia
Pro5® MHC Pentamers used in conjunction with ProPresent® Antigen Presentation Assays to identify MHC class I epitopes in AAV vectors that trigger cytotoxic T cell responses when presented by hepatocytes

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Hepatitis (HBV and HCV)

Adam Gehring, Singapore Institute for Clinical Science
Phenotypic Analysis of HBV-specific T Cells Using Pro5® Pentamers

Victoria Kasprowicz, University of KwaZulu Natal
A Story of Viral Escape Through Sequence Variation in Chronic Hepatitis C Virus Infection

Lars Frelin, Karolinska Institute
Developing a Therapeutic Hepatitis B Vaccine with Pro5® Pentamers

Eleanor Barnes, University of Oxford
Success for Hepatitis C Vaccine Trials at Oxford University

Tanja Lange, University of Lübeck
Sleep Your Way to Better Immunity – Sleep After Vaccination Boosts Immunological Memory

More Hepatitis Publications Citing ProImmune

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HIV

Samantha Westrop, Chelsea & Westminster Hospital
ProImmune REVEAL & ProVE® Rapid Epitope Discovery System used to Identify Novel T Cell Epitopes in HIV-1

Jorge Almeida, INSERM
T Cell Vaccines for HIV-1 Move a Step Closer – Researchers Use HIV-specific Pro5® MHC Class I Pentamers Combined with Intracellular Cytokine Staining

Aude Chapuis, Fred Hutchinson Cancer Research Center, USA
Sending in Trained Killers to Attack Residual HIV Infection

University of Manitoba Researchers Use PEPscreen® Library for Epitope Mapping

Tarmo Mölder, University of Tartu
HIV Vaccine Study in Pigs Uses PEPscreen® Peptides in ELISpot Assays

More HIV Publications Citing ProImmune

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Infectious Diseases

Paul Arnaboldi, New York Medical Center Diagnostic Peptide Epitope for Lyme Disease Identified with ProArray Ultra®    Sanja Selak, Intercell AG Developing Effective Vaccine Strategies for Complex Pathogens Maziar Divangahi, Harvard Medical School, USA A Messy End for TB-infected Macrophages Ana Ferreira, Instituto Gulbekian de Ciência, Portugal Researchers Show How Inheritance of Sickle Cell Anemia Protects Against Malaria Infection

Virginie Roupie, Scientific Institute of Public Health, Brussels
PEPscreen® Used in Vaccine Development for Mycobacterium Tuberculosis

Cyrille Bisseye, Medical Research Council UK and The Gambia
Designing a Malaria Vaccine

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Influenza

J Guo, University of Texas
Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging

Roberto Mallone, Hôpital Saint Vincent de Paul
How Does Blood Processing Affect the Results of Cell Mediated Immunity Assays? ProImmune’s Flu Pro5® MHC Class I Pentamer is Used as an Exemplar in an Exploratory Study

Sohail Ahmed, Novartis
ProImmune REVEAL® MHC Peptide Binding Assays used by team at Novartis and Stanford University to investigate immunological insights into the causation of narcolepsy associated with pandemic H1N1 influenza vaccine Pandemrix®

More Influenza Publications Citing ProImmune

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NKT Cells and CD1d

Patricia Barral, Cancer Research UK ProImmune CD1d Tetramers Provide Novel Insights Into NKT Cell Activation        Stefan Porubsky, DKFZ The Significance of Isoglobotrihexosylceramide (iGb3) as the Natural CD1d Ligand in Mice Maya Fedeli, H San Raffaele Scientific Institute NKT Cell Differentiation Depends on Dicer Processing of MicroRNA

Thierry Mallevaey, INSERM
NKT Cells are Important in the Acquired Immune Response During Helminthiasis

Omar Duramad, Regimmune
ProImmune’s Human CD1d Tetramer Detects NKT Cells from Non-human Primates

More Publications Citing ProImmune CD1d Tetramers

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Other Viral diseases

Defence Science and Technology Laboratories, UK
The Human Side of Counter-Bioterrorism: T Cell Proliferation Assays Validate Humanization of an anti-VEEV Antibody

Gene Olinger, USAMRIID
ProImmune’s Antigen Characterization Platform Accelerates Development of a Vaccine for Ebola and Marburg Viruses

Giovanna Rappocciolo, University of Pittsburgh
ProImmune’s REVEAL & ProVE® Rapid Epitope Discovery System Validates Novel Epitopes Important for CD8+ T Cell Control of Human Herpesvirus 8

Andre Oliveira, University College Dublin
ProImmune REVEAL and ProVE® Used to Identify First HTLV-2 MHC Class I Epitope

Pim van der Heiden, Leiden University Medical Center
Discovery of First VZV HLA-A2 Epitope, Using ProImmune REVEAL & ProVE® Technology

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Transplantation

Bruce Blazar, University of Minnesota In Situ Identification of Allospecific B Cells using Pentamers

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