ProM1® MHC Class I Monomers - Catalog

MHC Class I-peptide complexes bind to CD8+ T cell receptors of a particular specificity, as determined by the MHC allele and peptide combination. In addition to their use (as streptavidin-conjugated MHC tetramers) in the identification of specific CD8+ T cells by flow cytometry, biotin-labeled MHC
Class I monomers can be used to isolate (or deplete) antigen specific
CD8+ T-cells through the use of streptavidin-coated magnetic microbeads.

Isolation of antigen-specific T cells in this manner is useful if viable
cells are needed for downstream applications. Biotin-labeled ProM1TM MHC Class I Monomers can also be immobilised on streptavidin-coated surfaces for use in plate based assays such as ELISA.

Class I Monomers are available in 35 ug and 100 ug quantities.